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Plavix and/or Equivalent Clopidogrel Prescription Information

Plavix, a Thienopyridine Antiplatelet class drug, contains the active ingredient Clopidogrel Bisulfate which inhibits Blood Coagulation. It is used in various conditions such as Coronary Artery Disease (CAD), Peripheral Vascular Disease, and Cerebrovascular Disease (CVD). Available by prescription only.

Because of unfavorable food habits and environmental condition, the risk of stroke or heart attack in patients is increasing day by day. Researchers have been undertaking research activities on a regular basis to find out a medication that can combat with heart or circulatory problems. And as a result, they have come up with a unique solution in the form of Plavix. It is a medication which is used to reduce the chance of stroke or heart attack in patients who have had heart attack or stroke any time in their life. The medication is also used in the management of treatments relating to Circulatory Problems. It slows down or stops platelets to form blood clots in the heart or blood vessels. One should buy Plavix only when it is prescribed by a licensed physician.

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A few essential facts of Plavix are mentioned below:

• Avoid taking the drug if you spot some allergic reactions in your body.
• It is better to stop using Plavix immediately if you are suffering from active bleeding disorders such as stomach ulcer or vaginal bleeding.
• If you are pregnant or breast-feeding, you must seek advice from your physician before using the pill. Plavix may be harmful for an unborn baby.
• Certain medications may interact with Plavix. So, inform your doctor beforehand if you are using other medications for a particular health condition. Plavix should not be used if you are taking non-steroidal anti-inflammatory drugs without your doctor's advice such as, buprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), etc.,
• While using Plavix, you may experience some potential and severe side effects such as incessant nose bleeding, black, bloody, or tarry stools, coughing up blood, chest pain, sweating, sudden numbness or weakness, pale skin etc.,

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If you follow the aforesaid instructions carefully, you will definitely get optimal result after using Plavix. In addition, you can also buy Plavix from an online drug store at a cheaper price. Add to this, online drug stores sell only FDA-approved medications with a view to safeguard your health. So, buy Plavix online to save money and to reduce the chance of stroke or heart attack.

Indication/Usage:

Plavix is approved for various indications, primarily in the prevention of blood coagulation/clotting after recent heart attack, myocardial infarction, or stroke. It is also used for the treatment of the following indications:

• Acute Coronary Syndrome (ACS), an unstable angina and non-Q-wave myocardial infarction (MI);
• Non-ST-segment Elevation MI (NSTEMI), and ST Elevation MI (STEMI);
• Reduction and prevention of atherosclerotic events like MI, refractory ischemia, stroke, and vascular death; and
• Prevention of Thrombosis after stent placement.

Dose, Administration and Dosage forms:

Plavix is available in 75 mg and 300 mg tablets. These tablets are administered orally as follows:

• Non-ST-segment Elevation ACS (NSTEMI): administered in combination with aspirin (75 mg to 325 mg once per day) as 300 mg in a loading dose which is followed by 75 mg once per day.
• STEMI: administered as 75 mg once per day in combination with aspirin (75-325 mg once daily), with or without a loading dose as well as with or without thrombolytic agents.
• Recent MI or stroke, and established peripheral arterial disease: 75 mg once per day.

Plaix should be stored at 59 F - 86 F (15 C - 30 C).

Since platelet aggregation inhibition is seen after two hours of a single dose of oral clopidogrel, a loading dose of 300 mg to 600 mg is usually administered to quicken onset of action.

Mechanism of action:

Plavix contains clopidogrel, a prodrug, which is a platelet activation and aggregation inhibitor. It acts via irreversible binding by its active metabolite at platelet receptors. More specifically, the active metabolite binds at the P2Y12, which is a subclass of adenosine diphosphate (ADP) receptors on platelet cell membranes. P2Y12 is an important factor in platelet aggregation and cross-linking with the help of the protein fibrin. This blockage of the P2Y12 receptor results in the inhibition of platelet aggregation via inactivation of the glycoprotein IIb/IIIa pathway. The inactivation results in the inhibition of platelet aggregation and cross-linking by the fibrin.

Side-effects and safety profile:

Because most of the clinical trials of Plavix compare with Aspirin rather than a placebo, it is difficult to report side-effects attributing directly to Plavix.

Various non-serious side-effects reported in research studies involving Plavix include: edema, cough, diarrhea, rash, upper GI discomfort, nausea, dyspepsia, myalgia, arthralgia, headache, altered taste, etc. These side-effects can be treated with normal therapies.

Serious side-effects reported during clinical trials and post marketing studies include: severe neutropenia, thrombotic thrombocytopenic purpura (TTP), agranulocytosis, aplastic anemia/pancytopenia, gastric or duodenal ulcer, gastritis, pancreatitis, stomatitis, colitis, upper respiratory tract infections, rhinitis, shortness of breath, chest pain, fever, acute liver failure, hepatitis, abnormal liver function test (LFT), serum sickness, arthritis, confusion, hallucinations, bronchospasm, increased creatinine levels, interstitial pneumonitis, hypotension, vasculitis, eczema, erythema multiforme, generalized pruritus, Stevens-Johnson syndrome, urticaria, bullous dermatitis, necrolysis, etc.

Severe hemorrhages reported with Plavix include gastrointestinal, cerebral, post-operative, intracranial, conjunctival, ocular, retinal, musculoskeletal, respiratory tract, and skin hemorrhages. Patients experiencing any of the above serious side-effects should seek immediate medical care.

Warnings/Contraindications:

• Poor metabolizers will experience diminished effectiveness,
• Plavix is contraindicated in those who are allergic to clopidogrel,
• Plavix is contraindicated in any active bleeding like stomach ulcers or bleeding in the brain,
• Patient must discuss various conditions with prescribing physician for appropriate dose titration. These conditions include bleeding or blood clotting disorders, a history of stroke/mini-stroke, ulcerative colitis, and kidney disease.
• Plavix is an FDA pregnancy category B drug and is not expected to be harmful to the fetus.
• Patients taking Plavix must avoid any concomitant therapy containing omeprazole or esomeprazole,
• Plavix must be discontinued appropriately as premature discontinuation increases the risk of cardiovascular events.

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