Mechanism of Action:
Tamoxifen is a prodrug which is metabolized in the liver by the cytochrome P450 into active metabolites such as 4-hydroxytamoxifen and N-desmethyl-4-hydroxytamoxifen. These active metabolites have 30-100 times more affinity than tamoxifen toward estrogen receptors and thereby competitively inhibit and prevent the binding of estrogen to the estrogen receptors. Since various breast cancer cells require estrogen for their normal growth, this lack of estrogen at the cellular level blocks breast cancer cell growth by decreasing DNA synthesis.
Side-effects and Safety Profile:
Side-effects of moderate severity reported with tamoxifen usage include: hair thinning, tumor related pain, depression, hot flashes, headache, fever, chills, body aches, bone and joint pain, dizziness, numbness, purple or red pinpoint spots under the skin, restlessness, weakness, hands or feet swelling, nausea, increased thirst, loss of appetite, upper stomach pain, vaginal dryness and itching, suppressed sexual drive, impotence and difficulty in reaching orgasm, etc.
Warnings/Contraindications:
- Tamoxifen is contraindicated in patients who are allergic to it.
- Tamoxifen is contraindicated for those patients who need concomitant warfarin anticoagulation treatment because of deep vein thrombosis (DVT) and/or pulmonary embolus.
- Tamoxifen may cause uterine cancer, strokes, and blood clotting with a serious or fatal outcome. Patients must discuss any history of stroke, heart attack and blood clotting with their physician.
- Patients should tell their doctor if they smoke or have high blood pressure, diabetes, or impaired walking ability before taking tamoxifen.
- Genital organs should be regularly monitored and examined for early signs of uterine cancer.
- Tamoxifen is classified as a pregnancy category D drug, meaning it may cause fetal harm; therefore, it should not be prescribed to pregnant women.
- Studies have not been performed on nursing mothers to determine whether tamoxifen excretes in breast milk. Therefore, tamoxifen should be prescribed in nursing women only if the potential benefit justifies the risk to the baby.
Ordering Tamoxifen Online
Do you have questions about purchasing Tamoxifen online? Call 1-877-275-1525 or contact us through another method. Once you have placed your order for Tamoxifen, you will be provided with instruction on how to submit your doctors prescription. Orders for Tamoxifen will not ship until we receive your prescription.
Price Guarantee
Our mission at CanadaDrugPharmacy.com is to cheap Tamoxifen at the best price along with exceptional customer service. We are so confident we have Tamoxifen at the lowest price, if you find a better price online, use the price beat feature next to the medication and we will beat it.
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Nolvadex (Tamoxifen)
